Sebastian Mafeld
Site Director, Toronto Western Hospital
Dr. Sebastian Mafeld is a vascular & interventional Radiologist at University Health Network (UHN) and Sinai Health in Toronto, Canada. He works within a team to provide vascular and non-vascular minimally invasive procedures involving aortic and peripheral arterial interventions, balloon pulmonary angioplasty, dialysis access, embolization, hepato-biliary/urological intervention, interventional oncology and management of venous disease. He also reports vascular imaging studies including CT, MRI, and ultrasound.
Dr. Mafeld is active in multiple clinical trials, as well as the education of fellows, residents and medical students. He also has an interest in endovascular simulation. A list of Dr. Mafeld’s publications can be found here.
He serves on the editorial board for The Canadian Association of Radiologists Journal and is a reviewer for several other journals.
Dr. Mafeld is involved in multiple clinical trials, including but not limited to:
Principal Investigator
EMHSeed grant $120,000 CAD over two years. Jointly obtained with professor Matsuura’s lab to develop a novel temporary embolic agent for application in musculoskeletal embolization. Further $28,330 raised from the Academic Incentive Fund. PROSPECT multicentre trial for endovascular simulation
Principal Investigator
First in human device trial; CAPERE thrombectomy system. 2019 – Present
Co-Principal investigator
A Prospective North American Multicenter, Post Approval Study of the Lutonix Drug-Coated Balloon for dysfunctional dialysis fistulas. Becton Dickenson 2018-present
Co-investigator
Hemostemix trial
Co-investigator
Evaluation of prognostic value of 18F-Fluoroazomycin Arabinoside (FAZA) Positron Emission Tomography/Magnetic resonance imaging (PET/MR) in patients with critical limb ischemia pre-and post revascularization: A pilot study [FAZA Limb Ischemia]
Co-Investigator
$40,000 CAD Funding through AIF JDMI
Co-Investigator
Parallel cluster-randomized trial of the Integrated Pulmonary Index for nurse-administered procedural sedation. Support from Medtronic External Research Program. $63,500 to support direct research costs and ~$60,000 worth of equipment has been awarded Joint collaboration between JDMI and Cardiology
Co-Investigator
Automation of procedural fasting instructions. AMS Healthcare Small Grant in Compassion and Artificial Intelligence ($20,000)
- Vascular Closure Devices For Axillary Artery Access: A Systematic Review and Meta-Analysis
CONCLUSIONS: Off-label use of VCDs in the axillary artery provides an 85% successful closure rate and variable complication rate, depending on the […]
- The Use of Vascular Closure Devices for Brachial Artery Access: A Systematic Review and Meta-Analysis
CONCLUSIONS: Despite being off-label, studies suggest that VCDs in the brachial artery have a high technical success rate. There was no significant […]
- Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review and Meta-analysis
CONCLUSION: BPA represents a safe and effective treatment option for select individuals with CTEPH with significant improvements in hemodynamic […]
- Minimally invasive delivery of ethanol for the treatment of urinary bladder fistulas
Urinary bladder fistula formation is a complication of significant morbidity and mortality following pelvic surgery or radiotherapy. Surgical […]
- Wisdom in Interventional Radiology: There's More to Practice Than Just Technical Skills
No abstract
- Minimally Invasive Segmental Artery Coil Embolization (MISACE) Prior to Endovascular Thoracoabdominal Aortic Aneurysm Repair
CONCLUSIONS: MISACE is a promising strategy to prevent SCI. This data demonstrates the technique is feasible and safe but anatomic challenges remain.
- Utility of 4D CT in endoleak characterization after advanced endovascular aortic repair
CONCLUSIONS: 4D CT is a useful adjunctive tool in FB-EVAR surveillance with excellent sensitivity and specificity in characterizing endoleaks. This […]
- Uterine Artery Embolization for Pedunculated Subserosal Fibroids: A Systematic Review and Meta-Analysis
CONCLUSIONS: UAE for pedunculated subserosal fibroids has a low risk of adverse events and effectively reduces fibroid and uterine size.
- Integrated Pulmonary Index during nurse-administered procedural sedation: Study protocol for a cluster-randomized trial
AIM: To determine if smart alarm-guided treatment of respiratory depression using the Integrated Pulmonary Index is an effective way to implement […]
- Outcome after pulmonary endarterectomy for segmental chronic thromboembolic pulmonary hypertension
CONCLUSIONS: PEA achieved excellent early and long-term results in segmental chronic thromboembolic pulmonary hypertension. However, patients with […]
- Percutaneous Drainage for Aortic Graft Infection Post-aneurysm Repair: A Viable Option?
CONCLUSION: Percutaneous drainage of AGI following endovascular or open aneurysm repair is a safe and viable management option either as a […]
- SUPERA Stenting in the Common Femoral Artery: Early Experience and Practical Considerations
CONCLUSION: Endovascular intervention of the CFA is an evolving topic in the interventional radiology and vascular surgery community. Recent […]
- Endovascular coil embolization of inferior mesenteric artery to ileal-conduit fistula: a case report
CONCLUSIONS: Although UAFs are uncommon, our case demonstrated key predisposing risk factors to fistula development; pelvic cancer surgery, pelvic […]
- Assessment of open surgical and endovascular management of true hepatic artery aneurysms over 20 years highlights increased rupture risk in females
CONCLUSIONS: True HAAs are a rare but important clinical phenomenon, with 16% of patients presenting with rupture in this study. Endovascular […]
- Global trends in chronic thromboembolic pulmonary hypertension clinical trials and dissemination of results
Treatment options for chronic thromboembolic pulmonary hypertension (CTEPH) are rapidly expanding. The purpose of this study is to identify trends in […]
- Effect of vertebral compression fractures on aortic neck angulation after endovascular aneurysm repair
CONCLUSIONS: Post-EVAR vertebral body compression fractures exacerbate ANA. Awareness of this can guide both preoperative assessment and […]
- Percutaneous Transluminal Angioplasty for Below-the-Elbow Critical Hand Ischemia: A Systematic Review
CONCLUSIONS: PTA for CHI due to BTE obstructive arterial disease is feasible with a high technical success rate and a low short-term complication […]
- Predicting Prolonged Apnea During Nurse-Administered Procedural Sedation: Machine Learning Study
CONCLUSIONS: Decision curve analysis indicated that using a random forest model would lead to a better outcome for capnography alarm management than […]
- Endovascular Management of Unused Fenestrations or Branches in Fenestrated/Branched Aortic Endograft
Fenestrated and branched aortic endograft (F/B EVAR) has become a widely accepted technique in the management of aneurysmal aortic pathology. […]
- Evaluation and management of patients with chronic thromboembolic pulmonary hypertension - consensus statement from the ISHLT
ISHLT members have recognized the importance of a consensus statement on the evaluation and management of patients with chronic thromboembolic […]
- Characteristics of Imipenem/Cilastatin: Considerations for Musculoskeletal Embolotherapy
No abstract
- Endovascular community response to mortality data in use of paclitaxel devices for peripheral vascular disease
CONCLUSIONS: After the report of data with concerns of mortality associated with paclitaxel device use in 2018, a rapid reduction in overall […]
- Persistent sciatic artery presenting as an acutely ischemic limb
Persistent sciatic artery (PSA) is an extremely rare vascular phenomenon, with a prevalence of 0.025% to 0.04% in the general population. We present […]
- Arteries of the Lower Limb-Embryology, Variations, and Clinical Significance
CONCLUSION: Knowledge of these variations is essential for surgical and endovascular management as failure to recognize them can result in […]
- Randomized Controlled Trial of Percutaneous Radiologic Gastrostomy Performed With and Without Gastropexy: Technical Success, Patient-Reported Outcomes and Safety
CONCLUSION: There is comparable patient tolerability when balloon-retention PRG insertion is performed with or without gastropexy sutures. This study […]
- Midazolam for sedation before procedures in adults and children: a systematic review update
CONCLUSION: The additional evidence arising from inclusion of new studies in this updated review has not produced sufficient high-quality evidence to […]
- CT perfusion in peripheral arterial disease-hemodynamic differences before and after revascularisation
CONCLUSIONS: CTP seems feasible for assessing hemodynamic differences in calf muscles before and after revascularisation in patients with symptomatic […]
- The FEMME Trial: At Risk for Misinterpretation and "Fake News"
No abstract
- Adverse Outcomes after Advanced EVAR in Patients with Sarcopaenia
CONCLUSION: Measurement of tPMA can be a useful predictive tool for adverse outcomes after advanced EVAR.
- Ten-year trends in iliofemoral deep vein thrombosis treatment and referral pathways
CONCLUSIONS: The results of this analysis highlight the change in practice in our institution over time. The low rate of intervention likely reflects […]