Dr. Mikulis

Dr. David J. Mikulis

Dr. David Mikulis is Full Professor and Director of the Functional Neuroimaging Research Lab in the Joint Department of Medical Imaging at the University Health Network and the University of Toronto. The primary emphasis of this work has been translational research focusing on the application of novel imaging methods into the clinical environment.

Dr. Mikulis established one of the first fMRI labs in Canada in 1993 and is currently involved in developing advanced neurovascular imaging methods with major program arms including: 1) quantitative measurement and clinical application of cerebrovascular reactivity (CVR) metrics leading to the development of “the brain stress test” (analogous to the cardiac stress test) that assess the effectiveness of the cerebral circulatory system in meeting the metabolic needs of the brain; 2) high resolution and functional imaging of intra- and extra-cranial blood vessel walls that improves diagnostic accuracy for assessing diseases that directly affect blood vessels; 3) discovery of a new method for measuring brain blood flow that does not require injection of contrast agents.

Research in the above areas has improved assessment of the structure, function, and performance of the vascular system in health and disease. These capabilities have further defined the important roles that abnormal vascular performance measures have in the pathophysiology of a number of conditions including for example Alzheimer’s and vascular dementias, and in improving diagnostic accuracy of acute concussion.

Translation of these methods has been achieved locally, nationally, and internationally confirming the importance of these tools in research and clinical settings.

Recent Publications